Trophoblasts express Fas ligand: a proposed mechanism for immune privilege in placenta and maternal invasion D.Uckan1, A.Steele2, Cherry1, B.-Y.Wang1, W.Chamizo2, A.Koutsonikolis1, E.Gilbert-Barness3 and R.A.Good1,4
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چکیده
D.Uckan1, A.Steele2, Cherry1, B.-Y.Wang1, W.Chamizo2, A.Koutsonikolis1, E.Gilbert-Barness3 and R.A.Good1,4 1Department of Pediatrics, All Children’s Hospital, University of South Florida, 2Department of Pathology and Laboratory Medicine, All Children’s Hospital, 801 Sixth Street South, St. Petersburg, FL 33701, and 3Department of Pathology, Tampa General Hospital, Davis Island, B232, Tampa, FL 33601, USA 4To whom correspondence should be addressed
منابع مشابه
First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis.
Since the invading trophoblast represents a semi-allograft, it should be rejected by the mother. It has, therefore, been postulated that during normal pregnancy the trophoblast evades the maternal immune system though the establishment of immune privilege by triggering the death of activated lymphocytes which may be sensitized to paternal alloantigens. Such peripheral tolerance may be directed ...
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To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts res...
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Preeclampsia is a placenta-dependent disorder with both local and systemic anomalies with neonatal and maternal morbidity. It is manifested late in pregnancy, but the onset is during early stages of gestation. The current hypothesis regarding the aetiology of preeclampsia is focused on maladaptation of immune responses and defective trophoblast invasion. Thus, an excessive maternal inflammatory...
متن کاملPlatelet-endothelial cell adhesion molecule-1 is expressed by a subpopulation of human trophoblasts: a possible mechanism for trophoblast-endothelial interaction during haemochorial placentation.
The terminal event in the establishment of the haemochorial placenta in the human is the invasion of trophoblasts into the maternal vessels, a process in which trophoblasts interact directly with the vascular endothelium and degrade the vascular basement membrane and the tunica elastica of the vessels. To further understand this heterotypic cellular interaction, we investigated the expression b...
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تاریخ انتشار 1997